In short, McAfee Access Protection and Buffer Overflow Protection services are known to cause severe performance degradation during scanning or monitoring of several common Windows Server processes. The recommendation is to disable and remove these McAfee services. See the article for removal instructions.
http://blogs.technet.com/askperf/archive/2010/04/01/high-impact-issue-servers-may-become-unresponsive-due-to-multiple-issues.aspx
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